Artemether is contraindicated in conditions like Pulmonary edema,Hypersensitivity,Pregnancy,Cerebral malaria,QTc prolongation,Breast feeding.
The severe or irreversible adverse effects of Artemether, which give rise to further complications include Retinopathy, Neurotoxicity, QT prolongation.Artemether produces potentially life-threatening effects which include Cardiovascular depression, Cardiopulmonary arrest. which are responsible for the discontinuation of Artemether therapy.The signs and symptoms that are produced after the acute overdosage of Artemether include Vomiting, Convulsions, Coma, Cardiopulmonary arrest.The symptomatic adverse reactions produced by Artemether are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Anorexia, Diarrhea, Fever, Insomnia, Tinnitus, Abdominal pain, Sleep disturbancesX, Rashes, Urticaria, Pruritus, Itching, Sleep disturbance, Hypotension, Elevation of liver enzymes, Transient low fever, Abnormal gait, parasthesia, Decreased hearing.
Artemether is primarily indicated in conditions like Chloroquine resistant malaria, Complicated and severe malaria, Uncomplicated malaria.
Artemether is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementVORICONAZOLEAdditive QTc prolongation may occur.concomitant therapy should be avoided These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Drug should not be given to Pregnant Mothers, and Cardiac / Hypertensive Patients.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Care should be taken when using to treat the women being pregnant with in three months or patients with severe vomiting. Administeration of Artemether with drugs that are metabolized by Cytochrome Enzyme CYP 2D6 like Flecainide,Metoprolol,Imipramine,Amitryptaline,Clomipramine should be avoided and artemether should also be avoided with drugs that prolong QT interval