Amobarbital is a barbiturate, used as a hypnotic and sedative. Amobarbital is now rarely recommended because of its adverse side effects and dependence.

Adult Dose
Dose: 30 to 50 mg
Single Dose: 40 (40)
Frequency: As recommended.
Route: IM/IV
Instructions: This dose is for day time sedation. To be taken 2-3 times a day.
Single Dose:
Amobarbital also known as Amylobarbitone. . It is of Synthetic origin. . The Molecular Weight of Amobarbital is 226.13.
Amobarbital is contraindicated in conditions like Pregnancy,Porphyria,Breast feeding,Heterozygous familial hypercholesterolaemia,Hyperlipidaemias, see instruction,Central retinal venous/arterial thrombosis.
The symptomatic adverse reactions produced by Amobarbital are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Ataxia, Confusion, Respiratory depression, Hypersensitivity reactions, Hangover with drowsiness, Paradoxical excitement, Precede sleep.
Amobarbital is primarily indicated in conditions like Prophylaxis of NSAID-associated gastric or duodenal ulcer.
Amobarbital is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementAbacavirAnticonvusant effect of barbiturates (e.g Amobarbital antagonised by Fluoxetine and other SSRIs; convusive threshold lowered. Clomiphene (Citrate)Cyclosporin AAmlodipine accelerates the metabolism of cyclosporin (reduced effects).Diltiazem (HCl)Barbiturates reduces hypotensive effects of Diltiazem.MajorEstrogens ConjugatedAmobarbital accelerates the metabolism of estrogen; reduced contraceptive effect.MajorFelodipineBarbiturates reduces hypotensive effects of Felodipine.MajorHydrocortisoneAmlodipine accelerates the metabolism of Hydrocortisone (reduced effects).Indinavir (Sulphate)Barbiturates possibly reduces plasma concentration of indinavir.MajorIprindoleTheoretical potential for AMOBARBITAL increasing the CONVULSANT effect of IPRINDOLE.ModerateMay need to avoid combination.IsradipineBarbiturates reduces hypotensive effects of Calcium-channel blockers (e.g Isradipine).MajorLofepramine (HCl)Theoretical potential for AMOBARBITAL increasing the CONVULSANT effect of LOFEPRAMINE. ModerateMay need to avoid combination. NelfinavirAmobarbital possibly reduces plasma concentration of Nelfinavir.MajorPotassium ClorazepateEffects of Potassium Clorazepate may be potentiated by Amobarbital.Prednisolone and PrednisoneAmlodipine accelerates the metabolism of Prednisolone (reduced effects).ProgesteroneAmobarbital accelerates the metabolism of estrogen; reduced contraceptive effect.MajorSaquinavirBarbiturates possibly reduces plasma concentration of indinavir.MajorVerapamil (HCl)Barbiturates reduces hypotensive effects of Verapamil.MajorVORICONAZOLEAmobarbital may reduce serum concentrations and efficacy of voriconazole. Concomitant voriconazole and long-acting barbiturates therapy is contraindicated These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Tabs,Caps Store in a well closed container, . Protect from Sunlight and Heat.
Avoid use where possible; dependence and tolerance readily occur,abrupt withdrawl may precipitate serious withdrawl syndrome (rebound insomnia ,anxiety, tremor, dizziness, nausea, convulsions, delirium, and death), repeated doses are cumulative and may lead to excessive sedation, respiratory disease, renal disease, hepatic impairment. DRIVING: Drowsiness may persist the next day and affect performance of the skilled tasks (e.g driving); effects of alcohol enhanced.
Back to List

Any information that appears on this website page is provided for the purpose of general information. This website has been compiled in good faith by HMIS.Online. However, no guarantee is made as to the completeness, validity or accuracy of the information it contains.