Azapropazone is a non-steroidal anti-inflammatory drug (NSAID). Azapropazone is a weak inhibitor of cyclooxygenase, but possesses potent uricosuric activity, therefore particularly useful for the treatment of acute gout. Azapropazone is also used for the treatment of rheumatoid arthritis, osteoarthritis.

Adult Dose
Dose: 600 mg
Single Dose: 600 (600)
Frequency: 12 hourly
Route: PO
Instructions: The dose can be decreased to 900mg/day and incresed upto 1800mg/day. _x000D_For renal impaired function: Starting dose is 300mg in the morning and 600 mg at night._x000D_For much older patients(more than 65 years):Starting dose is 600mg at night or 300 mg twice daily.
. It is of Synthetic origin. . The Molecular Weight of Azapropazone is 300.40.
Azapropazone is contraindicated in conditions like Peptic ulcer,Blood disorders.
The severe or irreversible adverse effects of Azapropazone, which give rise to further complications include Hepatitis, Pulmonary fibrosis, Erythema multiforme, Agranulocytosis.Azapropazone produces potentially life-threatening effects which include Autoimmune hemolysis, Non-oliguric renal failure, Coombs +ve hemolytic anemia, Acute intestinal nephritis. which are responsible for the discontinuation of Azapropazone therapy.The symptomatic adverse reactions produced by Azapropazone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Photosensitivity.
Azapropazone is primarily indicated in conditions like Acute gout attack, Rheumatoid arthritis.
Azapropazone is known to interact with other drugs, the details of drug interactions is as follows:DrugDetailsSeverityOnsetManagementCyclosporin AFosphenytoinLithiumMethotrexatePhenytoin (Na)TacrolimusWarfarin (Na)Anticoagulant effect seriously enhanced by azapropazone.AVOID CONCOMITANT USE.Zidovudine These interactions are sometimes beneficial and sometimes may pose threats to life. Always consult your physician for the change of dose regimen or an alternative drug of choice that may strictly be required.
Drug should not be given to patients suffering from Kidney dysfunction, and patients suffering from Liver Malfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Caps, Tabs Store . Protect from Sunlight, Moisture and Heat.
It should not be given in patient with peptic ulceration and should be used with caution in patient with a history of such disorders and with infection, asthma or allergic disorder, impaired renal, hepatic or cardiac function, in elderly and may need to be given in reduce doses. To reduce he risk of gastrointestinal effects, the drug may be taken with or after food or milk.
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